Macroautophagy
Identifieur interne : 001E21 ( Main/Exploration ); précédent : 001E20; suivant : 001E22Macroautophagy
Auteurs : Adrienne M. Hannigan [Canada] ; Sharon M. Gorski [Canada]Source :
- Autophagy [ 1554-8627 ] ; 2009.
Abstract
Dietary compounds can influence the risk of cancer and other diseases through diverse mechanisms which include the activation or inhibition of macroautophagy. Macroautophagy is a catabolic process for the lysosomal degradation and recycling of cytoplasmic constituents which has been implicated in several pathologies, including cancer and neurodegeneration. In some instances, macroautophagy acts to suppress tumor formation and neural degeneration. Thus, it may be feasible to design diets, supplements or therapeutics that can alter the level of macroautophagy within cells to prevent or treat disease. While critical questions still need to be answered before we can safely and effectively implement such a strategy, we provide here a review of the literature regarding dietary constituents that have a demonstrated macroautophagy-modulating function.
Url:
PubMed: 19098459
PubMed Central: 3135626
Affiliations:
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Le document en format XML
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Gorski</name><affiliation wicri:level="1"><nlm:aff id="A1"> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19098459</idno><idno type="pmc">3135626</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135626</idno><idno type="RBID">PMC:3135626</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000406</idno><idno type="wicri:Area/Pmc/Curation">000406</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000406</idno><idno type="wicri:Area/Pmc/Checkpoint">000B09</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B09</idno><idno type="wicri:Area/Ncbi/Merge">000A05</idno><idno type="wicri:Area/Ncbi/Curation">000A05</idno><idno type="wicri:Area/Ncbi/Checkpoint">000A05</idno><idno type="wicri:Area/Main/Merge">001F70</idno><idno type="wicri:Area/Main/Curation">001E21</idno><idno type="wicri:Area/Main/Exploration">001E21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Macroautophagy</title><author><name sortKey="Hannigan, Adrienne M" sort="Hannigan, Adrienne M" uniqKey="Hannigan A" first="Adrienne M." last="Hannigan">Adrienne M. Hannigan</name><affiliation wicri:level="1"><nlm:aff id="A1"> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Gorski, Sharon M" sort="Gorski, Sharon M" uniqKey="Gorski S" first="Sharon M." last="Gorski">Sharon M. Gorski</name><affiliation wicri:level="1"><nlm:aff id="A1"> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> The Genome Sciences Centre; British Columbia Cancer Agency; Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A2"> Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, British Columbia, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea> Department of Molecular Biology and Biochemistry; Simon Fraser University; Burnaby, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j">Autophagy</title><idno type="ISSN">1554-8627</idno><idno type="eISSN">1554-8635</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Dietary compounds can influence the risk of cancer and other diseases through diverse mechanisms which include the activation or inhibition of macroautophagy. Macroautophagy is a catabolic process for the lysosomal degradation and recycling of cytoplasmic constituents which has been implicated in several pathologies, including cancer and neurodegeneration. In some instances, macroautophagy acts to suppress tumor formation and neural degeneration. Thus, it may be feasible to design diets, supplements or therapeutics that can alter the level of macroautophagy within cells to prevent or treat disease. While critical questions still need to be answered before we can safely and effectively implement such a strategy, we provide here a review of the literature regarding dietary constituents that have a demonstrated macroautophagy-modulating function.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Hannigan, Adrienne M" sort="Hannigan, Adrienne M" uniqKey="Hannigan A" first="Adrienne M." last="Hannigan">Adrienne M. Hannigan</name></noRegion><name sortKey="Gorski, Sharon M" sort="Gorski, Sharon M" uniqKey="Gorski S" first="Sharon M." last="Gorski">Sharon M. Gorski</name><name sortKey="Gorski, Sharon M" sort="Gorski, Sharon M" uniqKey="Gorski S" first="Sharon M." last="Gorski">Sharon M. Gorski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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